For the most part this campaign, Parkinson has enjoyed the luxury of being able to choose from a virtually fully-fit squad of players for the Bantams' early Sky Bet League 1 fixtures.
With a few players currently carrying knocks in the camp though, plus Rory McArdle and Carl McHugh both away on international duty at present, changes to City's starting eleven and bench could be in the pipeline for Sunday.
If any alterations to Parkinson's line up are required, however, it won't be the first time players have had to step up and play their part. Luke Oliver has twice deputised for McArdle in central defence already this season, while Mark Yeates played instead of the injured Nahki Wells at Walsall last weekend.
Parkinson said:"Just recently we've had some disruption for the first time through injury, but we've now got players I'm very confident can come in and make a contribution and we will definitely need all of them.
"We have some very good players in our squad who have perhaps been unlucky not to feature more than they have done already. We have the quality required within the squad for players to come in and play their part."
Although he is on the road to recovery from his ankle injury, Wells is expected not to be risked against Tranmere.
Parkinson added: "Nahki is making good progress. It isn't a major injury for him but we have to make sure he is right before we bring him back in.
"Yeatesy offered us something different at Walsall last weekend, while we also had Caleb (Folan) and Alan Connell on the bench as further options."