Rouven Sattlemaier replaces Colin Doyle in goal for City's quarter-final tie, while Stephen Darby takes the place of the suspended Tony McMahon at right back.
Timothee Dieng returns to midfield, with the Frenchman set to feature alongside Nicky Law, Josh Cullen and Mark Marshall.
Billy Clarke and Jordy Hiwula are expected to be partnered together in attack.
Matthew Kilgallon is sidelined with a shoulder problem and fellow defender Nathaniel Knight-Percival is ruled out due to a twisted ankle.
Alex Jones and Alex Gilliead are both cup-tied.
Young professionals James King and Ellis Hudson join Doyle and Daniel Devine on the Bantams' bench at the Kassam Stadium.
| OXFORD UNITED | BRADFORD CITY |
| 1. Simon Eastwood | 12. Rouven Sattelmaier |
| 5. Curtis Nelson (c) | 2. Stephen Darby |
| 8. Liam Sercombe | 3. James Meredith |
| 14. Josh Ruffels | 4. Nicky Law |
| 15. Kane Hemmings | 6. Romain Vincelot (c) |
| 16. Phil Edwards | 7. Mark Marshall |
| 18. Joe Rothwell | 8. Timothee Dieng |
| 19. Robert Hall | 10. Billy Clarke |
| 20. Ryan Taylor | 11. Jordy Hiwula |
| 28. Marvin Johnson | 14. Josh Cullen |
| 33. Chey Dunkley | 23. Rory McArdle |
| Substitutes: | Substitutes: |
| 24. Jack Stevens (GK) | 1. Colin Doyle (GK) |
| 4. John Lundstram | 21. James King |
| 10. Chris Maguire | 24. Daniel Devine |
| 11. Alex MacDonald | 32. Ellis Hudson |
| 23. Ryan Ledson | |
| 27. Jordan Graham | |
| 35. Canice Carroll |