Despite not being at their best, City still had a number of scoring chances during their visit to Roots Hall but they eventually succumbed to a 3-0 loss at the hands of the Shrimpers.
After a disappointing journey south, McCall hopes City can return to winning ways when his side entertain Northampton Town on home soil this Tuesday evening.
McCall said: "We know there will be plenty of highs and lows in any season, and Saturday wasn't our greatest performance certainly.
"We've had our moments but I feel Southend were a bit more clinical in taking their chances than we were.
"We move on from that now though. I felt our performance at Southend wasn't too bad, and we now have the opportunity to try and bounce back on Tuesday night.
"There were some positives from our display at Southend but we will look to be better on Tuesday and to go for the three points.
"It is a quick turnaround from Saturday and Southend but the lads will be keen to get back out there.
"We will look at our options for the game and if we want to make changes but, equally, there will be lads who will want to go again after perhaps putting in under-par performances by their standards at Southend.
"It is nice to have the chance to get out there quickly and to do better."