The tie - City's first outing in the month of December - will kick off at 7:45pm.
The prize for the winners of Wednesday's tie is £20,000 and a place in the round of sixteen.
The draw for the round of sixteen is unseeded, meaning northern and southern sides can meet each other - home or away - for the first time in the competition this season.
Should Wednesday's tie with Cambridge remain level after normal time, the game will then be decided by penalty kicks. There will be no extra time period.
The Club are making the lower tier of the JCT600 (Main Stand) available, plus the lower tier of the Kop at present for this game, subject to demand.
Admission prices are:
* Concessions are senior citizens over 60, students in full time education and under 16s
Disabled fans will be asked to pay the age-related amount from the list above.
They will be entitled to a free carer ticket subject to receiving either DLA or PIP at the mid or high levels.
Supporters can either purchase their tickets for this match from the ticket office now or pay on the turnstiles on the night.
Turnstiles on match-day will be for cash transactions only, however.
Any supporters wishing to buy their tickets via card must do so from the ticket office.
Fans cannot purchase Cambridge match tickets online.
The Trophy’s prominent rules
- Should any knock-out game finish level after 90 minutes, the match will go straight to penalties. There will be no extra time period.
- The winners of all round two ties will be entered into an unseeded draw for the round of sixteen, this means that northern and southern sides can meet each other (home or away) for the first time in the competition.
- All League One and League Two sides MUST field at least five players from the starting XI which began their previous (or next) league game OR five out of their list of top eleven starters in league and cup games so far this season.
- field at least six players out of their starting XI who were aged under 21 by 30 June 2016.MUSTEach invited Category 1 club (Premier League, Championship sides)
- Teams can name up to seven substitutes for each match but only a maximum of three can be used throughout the course of the game.
- The Trophy will be treat as a stand-alone competition for disciplinary matters. This means that any suspensions picked up through yellow cards and red cards collected in the Checkatrade Trophy will be served out in the trophy itself. For example, should a player be sent off in a Checkatrade Trophy match, they will serve out the suspension in their next Checkatrade Trophy match, NOT the next league game.