Paul Anderson and Jordy Hiwula have been brought into the side to replace Mark Marshall and Filipe Morais respectively.
Hiwula is expected to partner James Hanson in attack at the Wham Stadium, with Billy Clarke scheduled to start just behind the pair in an attacking midfield role.
After impressing on his first start in senior football against Port Vale on Saturday, Daniel Devine keeps his place in City's starting XI. Devine is set to feature alongside Anderson and Nicky Law in a three-man midfield.
Romain Vincelot will continue to partner Nathaniel Knight-Percival in central defence.
Matthew Kilgallon has remained in Bradford as the defender continues to build on his fitness levels.
New loan signing Josh Cullen has not been selected as well after playing virtually a full game for West Ham United against Juventus on Sunday in the Hammers' official opening game of their new home ground, the London Stadium.
|ACCRINGTON STANLEY||BRADFORD CITY|
|1. Elliot Parish||1. Colin Doyle|
|2. Matty Pearson||3. James Meredith|
|3. Mark Hughes||4. Nicky Law|
|4. Arron Davies||6. Romain Vincelot|
|5. Omar Beckles||9. James Hanson|
|7. Jordan Clark||10. Billy Clarke|
|9. Terry Gornell||11. Jordy Hiwula|
|27. John O'Sullivan||16. Paul Anderson|
|28. Seamus Conneely (c)||22. Nathaniel Knight-Percival|
|30. Janio Donacien||24. Daniel Devine|
|33. Chris Eagles||29. Tony McMahon (c)|
|20. Aaron Chapman (GK)||12. Rouven Sattelmaier (GK)|
|10. Shay McCartan||7. Mark Marshall|
|12. Callam Jones||20. Filipe Morais|
|14. Rommy Boco||25. Reece Webb-Foster|
|16. Bastien Hery||31. Kwame Boateng|
|17. Paddy Lacey|
|18. Steven Hewitt|