The game will be sixth time Phil Parkinson has took charge of City against the Blades after four previous league fixtures and one dramatic Johnstone's Paint Trophy tie won by the Bantams on penalties.
The match will also be third time Parkinson's men have taken on Sheff Utd on home soil in Sky Bet League 1.
With Sky Sports in the ground once again, United ran out 2-0 winners at Valley Parade last season, although Parkinson's men certainly weren't helped in the game by the sending off of skipper Stephen Darby just after the restart.
At 1-0 in the game midway through the second period, Jason Kennedy missed a golden opportunity to equalise for the ten-men when he headed narrowly wide from close range.
A loose touch by Andrew Davies due to an unfortunate bobble off the pitch seven minutes from the end then allowed Marc McNulty to race through and seal the points for the visitors.
The season before that - the 2013/2014 campaign - saw City triumphant in the home game, however, thanks to a well-taken double from Nahki Wells in front of over 18,000 fans at a bouncing Coral Windows Stadium.
City's most recent encounter with the Blades came back in April when Billy Clarke's leveller secured a 1-1 draw at Bramall Lane.
Clarke is one of three former Sheffield United players currently in City's squad, the other two being Tony McMahon and Steven Davies.
In the United camp, shot-stopper Mark Howard had a brief trial period with City under Peter Jackson back in the summer of 2011.
Down the years, there have been a large number of notable players to have played for both clubs in the recent past.
They include legendary former Bantams midfielder Stuart McCall, Bobby Campbell, Dean Windass, Chris Kamara, Andy Gray, Rob Kozluk, Kyel Reid Gus Uhlenbeek, Simon Francis, Keith Gillespie, John Egan, Nicky Law, Chris Wilder, Dean Saunders, Mark Yeates, Peter Beagrie, Danny Cadamarteri, Bruce Dyer, Michael Boulding, Richard Edghill, Lee Hendrie, Billy Paynter, Chris O'Grady, Kyle Nix, Marcel Seip and Jon Stead.