X-rays revealed Anderson has broken the tibia in his right leg, meaning the 27 year-old is likely to be sidelined now for roughly six to seven months.
Anderson picked up the injury after coming off worse from a crunching 50-50 tackle with Peterborough United midfielder Michael Bostwick during the first period of Saturday's Sky Bet League 1 fixture at the Coral Windows Stadium.
Anderson's broken leg is unfortunately the latest in a growing line of long-term injuries to affect Phil Parkinson's squad recently. Billy Clarke and Filipe Morais have also suffered serious knee injuries in the last couple of months.
With Josh Morris still expected to be sidelined for the next couple of games at least due to his own knee problem, Bantams boss Phil Parkinson admits City may now look into the loan market to bolster their options on the wing.
Parkinson said: "We need to have a look at our options.
"With Josh and Ando (Paul Anderson) out now, we may have to look at bringing a player in on loan.
"We look a little depleted in wide areas at the moment having lost a couple of key players."
Fans can pass on their messages of support to Paul by either e-mailing the club at bradfordcityfc@compuserve.com or via Paul's official Twitter page @P18NDO