Parkinson's will be without the quartet of Nathan Doyle, Ricky Ravenhill, Andrew Davies and Ritchie Jones - all midfielders or capable of playing in that area - for Saturday's trip to League 1 Notts County.
Ravenhill is sadly sidelined for three months with a knee injury, but it is hoped Doyle, Jones and Davies should all be in contention for next weekend.
The Bantams' Capital One Round One tie at Meadow Lane will be their first competitive match of the 2012/2013 campaign, coming just one week ahead of the beginning of City's League 2 season at Gillingham.
Parkinson said: "It's been a long pre-season for the lads and I know that they are desperate to get going with the real stuff now.
"We know we only have one more training session today (Friday) until we get the opportunity to get our season going. That prospect is something all the lads are looking forward to.
"Obviously we do have some slight problems in midfield, but we are all looking forward to getting that competitive element back into our matches.
"You can feel the buzz around the training ground now. All of the lads fit for selection are really up for it and ready to go again."
Parkinson acknowledges that County will go into Saturday's game as the bookies' favourites given their League 1 status but the Bantams boss says that won't stop his side from giving it a real go.
Parkinson added: "There are no real expectations on our shoulders - certainly most outsiders will see Notts County as favourites for the match. Hopefully that will allow us to go there and play with the freedom to express ourselves.
"Whatever team we settle on for Saturday's match, it will be one that will go out there with the intention to attack.
"We have some attacking options that we can use so we do have a bit of choice in that area."